Ngelixa kusenokwenzeka ukuba akukho buchwephesha bezonyango namhlanje obunokubakho ngakumbi, unyango lwe-stem cell alunazo iingxaki zabo. Iiseli ze-pluripotent stem (iPSCs) - ezo zenziwe elebhu emva kokuba zichithwe kwezinye iiseli zabantu abadala - ziya ngokulula ukwenza yonke imihla, kodwa zisabiza kakhulu ukwenza nokubeka emngciphekweni wokubangela iingxaki zempilo ezizezabo, mhlawumbi zide zibe nomhlaza. Iiseli ze-embryonic stem (ESCs) , Okwangoku, kubonisiwe ukuba kuyasebenza kwaye ikakhulu kukhuselekile kwizigulana, kodwa ukusetyenziswa kwabo kunyango kuhlala kungumbango. Iqela labaphandi abasebenza e IZiko leSalk kwaye i IYunivesithi yaseCalifornia San Diego uthathe inyathelo lokuqonda ukuba yintoni ebangela ukuba zombini ezi seli zikhathaze, nangona kunjalo. Baye Ufumene utyikityo olwahlukileyo lweemolekyuli ezibonisa xa iseli yesinti yenziwe kwilebhu endaweni yokuvunwa kwimbumba engafakwanga.
Xa ii-iPSCs ziguqulwa zisuka kwiiseli zabantu abadala zaya kwiiseli ezingafaniyo, ziye zitshintshe i-epigenetic-utshintsho kwi-DNA olunokuthi lutshintshe indlela eliziphethe ngayo, kwaye phantse lungaze lulunge. Kude kube ngoku, oososayensi bacinga ukuba olu tshintsho lwenzeka ikakhulu ngokungahleliwe. Uphando olutsha, lupapashwe kule veki kwi Iinkqubo ze-National Academy yeSayensi , ibonisa ukuba olo tshintsho ngenene lubandakanya utyikityo lweemolekyuli ezinokuvumela abaphandi bachonge xa iseli yesiqu yenziwe kwilebhu.
Abaphandi bajonga ii-iPSCs ezenziwe kwizihlunu ezahlukeneyo, zikhangela nawuphi na umsonto oqhelekileyo kumakhulu eenguqu ezincinci ezenziwe kwi-DNA yezo seli. Ngokwenza njalo, bayifumene kanye le nto bebeyikhangela-okanye ubuncinci indlela eya kuyo. Ngaphandle kotshintsho oluninzi olwenziwe kwi-DNA, utshintsho kwiijeni ezili-9 lwalusoloko lukhona kwii-iPSCs. Olo tshintsho luyi-9 lusebenza njengewotsermark yeeseli ezinamagama ezenziwe kwithishu yabantu abadala. Linyathelo lokuqala kuphela, kodwa ukuba nophawu lokuchonga kunika abaphandi ukuqonda okutsha ngumahluko phakathi kwe-iPSCs kunye nee-ESC, kwaye inokuba linyathelo lokuqala ekusombululeni iingxaki ngeeseli ezenziweyo elebhu kunye nokwenza unyango olunxulunyaniswe nabo lukhuseleke kwaye lusebenze ngakumbi .
(nge Umzimba )
- Kulungile ngokusesikweni ukuxhasa ngemali uphando lweeseli zesibeleko kwakhona, hurray!
- Ukuphembelela ipluripotency kuya kuba lula kwaye kulula nangona
- Akusekho nje, ngathi, kukhuselekile kakhulu okanye nantoni na
